反应详情

To a stirred solution of thionyl chloride (18 mL) in anhydrous methylene chloride (180 mL) was added (4-(4-fluorophenyl)-1H-imidazol-1-yl)methanol (11.4 g, 59 mmol) portionwise at RT under nitrogen. The reaction mixture was stirred at RT for 3.5 hr before anhydrous toluene (90 mL) was added. The mixture was stirred at RT for 30 min. Concentration under reduced pressure gave 1-(chloromethyl)-4-(4-fluorophenyl)-1H-imidazole hydrochloride (14.5 g, 59 mmol, 100% yield) as a solid. MS found: (M+H)+=211.3.

1. additionwas added
2. concentrationConcentration under reduced pressure