3,3-Diethoxypropyne → HCID 76621209, compound

Participants

Reaction Steps

250 mg (0.68 mmol) of (13) and 684 μl (4.77 mmol) of 3,3-diethoxy-propyne were dissolved in 3 ml of dioxane. 500 μl of saturated Cu(AcO)2 solution in H2O were added and the solution was stirred for 10 min. After pouring in ethyl acetate the organic layer was washed with saturated NaHCO3, water, brine and dried over Na2SO4. The crude product was dissolved in 500 μl THF with 10% of HCl and stirred for 1 h. The solution was poured in 20 ml of saturated NaHCO3 solution and extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over Na2SO4. The solvent was removed at the evaporator. The product was used in the next step without further purification.

Provenance & Evidence