反应详情

To a solution of 2-chloro-4′-(trifluoromethyl)acetophenone (50.9 g) and methyl 3-oxopentanoate (25 g) in toluene (500 mL) was added dropwise 1,8-azabicyclo[5.4.0]-7-undecene (28.7 mL) under ice-cooling over 30 min or longer. After the completion of the dropwise addition, and the mixture was stirred under ice-cooling for 30 min, and at room temperature for 2 hr. The resulting precipitate was filtered, and washed with toluene. The obtained toluene solution was passed through silica gel, and the silica gel was washed with ethyl acetate-hexane (1:1). The collected solution was concentrated under reduced pressure to remove ethyl acetate-hexane to give a toluene solution. To this toluene solution was added 4-toluenesulfonic acid monohydrate (7.2 g), and the mixture was stirred at 100° C. for 2 hr. The reaction mixture was washed with aqueous sodium hydrogen carbonate solution, and the aqueous layer was extracted with ethyl acetate. The organic layer was collected, and dried over magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (0% ethyl acetate/hexane to 10% ethyl acetate/hexane), and crystallized from ethyl acetate/hexane to give the title compound (16.3 g, 29%) as a white solid.

1. temperaturecooling over 30 min or longer
2. additionAfter the completion of the dropwise addition
3. temperaturecooling for 30 min
4. filtrationThe resulting precipitate was filtered
5. washwashed with toluene
6. washthe silica gel was washed with ethyl acetate-hexane (1:1)
7. concentrationThe collected solution was concentrated under reduced pressure
8. customto remove ethyl acetate-hexane
9. customto give a toluene solution
10. stirringthe mixture was stirred at 100° C. for 2 hr
11. washThe reaction mixture was washed with aqueous sodium hydrogen carbonate solution
12. extractionthe aqueous layer was extracted with ethyl acetate
13. customThe organic layer was collected
14. dry with materialdried over magnesium sulfate
15. customThe solvent was evaporated under reduced pressure
16. customThe residue was purified by silica gel chromatography (0% ethyl acetate/hexane to 10% ethyl acetate/hexane)
17. customcrystallized from ethyl acetate/hexane