Ethyl 3-(methylamino)propanoate → HCID 59529322, compound

HRID 1876939Notes

Reaction equation

HRID 1876939 reaction equation
[CH2:1]([C:3]1[O:4][C:5]([C:20]2[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=2)=[CH:6][C:7]=1[CH:8]([O:10][C:11]1[CH:19]=[CH:18][C:14]([C:15](O)=[O:16])=[CH:13][CH:12]=1)[CH3:9])[CH3:2].[CH3:30][NH:31][CH2:32][CH2:33][C:34]([O:36]CC)=[O:35]>>[CH2:1]([C:3]1[O:4][C:5]([C:20]2[CH:21]=[CH:22][C:23]([C:26]([F:28])([F:29])[F:27])=[CH:24][CH:25]=2)=[CH:6][C:7]=1[CH:8]([O:10][C:11]1[CH:19]=[CH:18][C:14]([C:15]([N:31]([CH3:30])[CH2:32][CH2:33][C:34]([OH:36])=[O:35])=[O:16])=[CH:13][CH:12]=1)[CH3:9])[CH3:2]

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68512355HCID 68512355, compound

Product 1

HCID 59529322HCID 59529322, compoundYield 99%

Procedure

An operation similar to that in Example 1 (4) was performed using 4-(1-{2-ethyl-5-[4-(trifluoromethyl)phenyl]-3-furyl}ethoxy)benzoic acid (121 mg) as well as ethyl 3-(methylamino)propanoate (47 mg) to give the title compound (145 mg, 99%) as an oil.

Sources & evidence

ORD record
ord-c8458ced17854459a9591c36d926e09e
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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