Ethyl 3-(methylamino)propanoate → HCID 59529342, compound

HRID 1876941Notes

Reaction equation

HRID 1876941 reaction equation
[CH2:1]([C:3]1[O:4][C:5]([C:23]2[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=2)=[CH:6][C:7]=1[CH:8]([O:13][C:14]1[CH:22]=[CH:21][C:17]([C:18]([OH:20])=O)=[CH:16][CH:15]=1)[CH2:9][CH:10]([CH3:12])[CH3:11])[CH3:2].[CH3:33][NH:34][CH2:35][CH2:36][C:37]([O:39]CC)=[O:38]>>[CH2:1]([C:3]1[O:4][C:5]([C:23]2[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:30])[F:31])=[CH:25][CH:24]=2)=[CH:6][C:7]=1[CH:8]([O:13][C:14]1[CH:22]=[CH:21][C:17]([C:18]([N:34]([CH3:33])[CH2:35][CH2:36][C:37]([OH:39])=[O:38])=[O:20])=[CH:16][CH:15]=1)[CH2:9][CH:10]([CH3:11])[CH3:12])[CH3:2]

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68512529HCID 68512529, compound

Product 1

HCID 59529342HCID 59529342, compoundYield 99%

Procedure

An operation similar to that in Example 1 (4) was performed using 4-(1-{2-ethyl-5-[4-(trifluoromethyl)phenyl]-3-furyl}-3-methylbutoxy)benzoic acid (179 mg) as well as ethyl 3-(methylamino)propanoate (67 mg) to give the title compound (203 mg, 99%) as an oil.

Sources & evidence

ORD record
ord-c96c3757bc3b4f9681aa0a51fd09235f
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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