Ethyl 3-(methylamino)propanoate → HCID 42610135, compound

HRID 1876945Notes

Reaction equation

HRID 1876945 reaction equation
[CH:1]1([CH:7]([NH:25][C:26]2[CH:34]=[CH:33][C:29]([C:30](O)=[O:31])=[CH:28][CH:27]=2)[C:8]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=3)[O:10][C:9]=2[CH2:23][CH3:24])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:35][NH:36][CH2:37][CH2:38][C:39]([O:41]CC)=[O:40]>>[CH:1]1([CH:7]([NH:25][C:26]2[CH:27]=[CH:28][C:29]([C:30]([N:36]([CH3:35])[CH2:37][CH2:38][C:39]([OH:41])=[O:40])=[O:31])=[CH:33][CH:34]=2)[C:8]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([C:19]([F:21])([F:22])[F:20])=[CH:15][CH:14]=3)[O:10][C:9]=2[CH2:23][CH3:24])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68512412HCID 68512412, compound

Product 1

HCID 42610135HCID 42610135, compoundYield 75%

Procedure

An operation similar to that in Example 1 (4) was performed using 4-[(cyclohexyl{2-ethyl-5-[4-(trifluoromethyl)phenyl]-3-furyl}methyl)amino]benzoic acid (118 mg) as well as ethyl 3-(methylamino)propanoate (39 mg) to give the title compound (104 mg, 75%) as an amorphous compound.

Sources & evidence

ORD record
ord-056e964f19094c47b383274e4ab3d294
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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