Ethyl 3-(methylamino)propanoate → HCID 59529477, compound

HRID 1876947Notes

Reaction equation

HRID 1876947 reaction equation
[CH:1]1([C:7]2[O:8][C:9]([C:23]3[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=3)=[CH:10][C:11]=2[CH2:12][O:13][C:14]2[CH:22]=[CH:21][C:17]([C:18](O)=[O:19])=[CH:16][CH:15]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:33][NH:34][CH2:35][CH2:36][C:37]([O:39]CC)=[O:38]>>[CH:1]1([C:7]2[O:8][C:9]([C:23]3[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:30])[F:31])=[CH:25][CH:24]=3)=[CH:10][C:11]=2[CH2:12][O:13][C:14]2[CH:22]=[CH:21][C:17]([C:18]([N:34]([CH3:33])[CH2:35][CH2:36][C:37]([OH:39])=[O:38])=[O:19])=[CH:16][CH:15]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68512011HCID 68512011, compound

Product 1

HCID 59529477HCID 59529477, compoundYield 95.3%

Procedure

An operation similar to that in Example 1 (4) was performed using 4-({2-cyclohexyl-5-[4-(trifluoromethyl)phenyl]-3-furyl}methoxy)benzoic acid (133 mg) as well as ethyl 3-(methylamino)propanoate (47 mg) to give the title compound (151 mg, 95%) as an amorphous compound.

Sources & evidence

ORD record
ord-c4039b7997a940e3b1f7dbebc6a710eb
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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