Ethyl 3-(methylamino)propanoate → HCID 59529549, compound

HRID 1876948Notes

Reaction equation

HRID 1876948 reaction equation
[CH:1]1([C:7]2[O:8][C:9]([C:24]3[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=3)=[CH:10][C:11]=2[CH:12]([O:14][C:15]2[CH:23]=[CH:22][C:18]([C:19](O)=[O:20])=[CH:17][CH:16]=2)[CH3:13])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:34][NH:35][CH2:36][CH2:37][C:38]([O:40]CC)=[O:39]>>[CH:1]1([C:7]2[O:8][C:9]([C:24]3[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:31])[F:32])=[CH:26][CH:25]=3)=[CH:10][C:11]=2[CH:12]([O:14][C:15]2[CH:23]=[CH:22][C:18]([C:19]([N:35]([CH3:34])[CH2:36][CH2:37][C:38]([OH:40])=[O:39])=[O:20])=[CH:17][CH:16]=2)[CH3:13])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68514216HCID 68514216, compound

Product 1

HCID 59529549HCID 59529549, compoundYield 84.3%

Procedure

An operation similar to that in Example 1 (4) was performed using 4-(1-{2-cyclohexyl-5-[4-(trifluoromethyl)phenyl]-3-furyl}ethoxy)benzoic acid (138 mg) as well as ethyl 3-(methylamino)propanoate (47 mg) to give the title compound (138 mg, 84%) as an amorphous compound.

Sources & evidence

ORD record
ord-0e36fbbe6a45439e8ce179ccd6704661
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

Loading…