Ethyl 3-(methylamino)propanoate → HCID 59529334, compound

HRID 1876949Notes

Reaction equation

HRID 1876949 reaction equation
[CH:1]1([C:7]2[O:8][C:9]([C:27]3[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][CH:28]=3)=[CH:10][C:11]=2[CH:12]([O:17][C:18]2[CH:26]=[CH:25][C:21]([C:22](O)=[O:23])=[CH:20][CH:19]=2)[CH2:13][CH:14]([CH3:16])[CH3:15])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:37][NH:38][CH2:39][CH2:40][C:41]([O:43]CC)=[O:42]>>[CH:1]1([C:7]2[O:8][C:9]([C:27]3[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:34])[F:35])=[CH:29][CH:28]=3)=[CH:10][C:11]=2[CH:12]([O:17][C:18]2[CH:19]=[CH:20][C:21]([C:22]([N:38]([CH3:37])[CH2:39][CH2:40][C:41]([OH:43])=[O:42])=[O:23])=[CH:25][CH:26]=2)[CH2:13][CH:14]([CH3:15])[CH3:16])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68509631HCID 68509631, compound

Product 1

HCID 59529334HCID 59529334, compoundYield 91.7%

Procedure

An operation similar to that in Example 1 (4) was performed using 4-(1-{2-cyclohexyl-5-[4-(trifluoromethyl)phenyl]-3-furyl}-3-methylbutoxy)benzoic acid (150 mg) as well as ethyl 3-(methylamino)propanoate (47 mg) to give the title compound (161 mg, 91%) as an amorphous compound.

Sources & evidence

ORD record
ord-f4c9f0e7a8fb4ad4b6b69ea234a3347b
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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