Ethyl 3-(methylamino)propanoate → HCID 59529558, compound

HRID 1876951Notes

Reaction equation

HRID 1876951 reaction equation
[CH:1]([C:4]1[O:5][C:6]([C:24]2[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=2)=[CH:7][C:8]=1[CH:9]([O:14][C:15]1[CH:23]=[CH:22][C:18]([C:19](O)=[O:20])=[CH:17][CH:16]=1)[CH2:10][CH:11]([CH3:13])[CH3:12])([CH3:3])[CH3:2].[CH3:34][NH:35][CH2:36][CH2:37][C:38]([O:40]CC)=[O:39]>>[CH:1]([C:4]1[O:5][C:6]([C:24]2[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:31])[F:32])=[CH:26][CH:25]=2)=[CH:7][C:8]=1[CH:9]([O:14][C:15]1[CH:23]=[CH:22][C:18]([C:19]([N:35]([CH3:34])[CH2:36][CH2:37][C:38]([OH:40])=[O:39])=[O:20])=[CH:17][CH:16]=1)[CH2:10][CH:11]([CH3:13])[CH3:12])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68514224HCID 68514224, compound

Product 1

HCID 59529558HCID 59529558, compoundYield 23%

Procedure

An operation similar to that in Example 1 (4) was performed using 4-(1-{2-isopropyl-5-[4-(trifluoromethyl)phenyl]-3-furyl}-3-methylbutoxy)benzoic acid (170 mg) as well as ethyl 3-(methylamino)propanoate (58 mg) to give the title compound (46 mg, 23%) as a white crystal.

Sources & evidence

ORD record
ord-1143fa7f1f3746a6acdf8afcfdfd416f
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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