Ethyl 3-(methylamino)propanoate → HCID 59529598, compound

HRID 1876952Notes

Reaction equation

HRID 1876952 reaction equation
[CH:1]1([CH:7]([C:18]2[CH:22]=[C:21]([C:23]3[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=3)[O:20][C:19]=2[CH:33]([CH3:35])[CH3:34])[O:8][C:9]2[CH:17]=[CH:16][C:12]([C:13](O)=[O:14])=[CH:11][CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:36][NH:37][CH2:38][CH2:39][C:40]([O:42]CC)=[O:41]>>[CH:1]1([CH:7]([C:18]2[CH:22]=[C:21]([C:23]3[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:30])[F:31])=[CH:25][CH:24]=3)[O:20][C:19]=2[CH:33]([CH3:35])[CH3:34])[O:8][C:9]2[CH:10]=[CH:11][C:12]([C:13]([N:37]([CH3:36])[CH2:38][CH2:39][C:40]([OH:42])=[O:41])=[O:14])=[CH:16][CH:17]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68509809HCID 68509809, compound

Product 1

HCID 59529598HCID 59529598, compoundYield 25%

Procedure

An operation similar to that in Example 1 (4) was performed using 4-(cyclohexyl{2-isopropyl-5-[4-(trifluoromethyl)phenyl]-3-furyl}methoxy)benzoic acid (195 mg) as well as ethyl 3-(methylamino)propanoate (63 mg) to give the title compound (57 mg, 25%) as an amorphous compound.

Sources & evidence

ORD record
ord-1da539df11d44cf292a6a26e51fb6e52
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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