Methyl acetoacetate → Methyl 2-methyl-5-[4-(trifluoromethyl)phenyl]-3-furoate

HRID 1876953Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1876953
Cl[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][CH:6]=1)=[O:4].[C:15]([O:21][CH3:22])(=[O:20])[CH2:16][C:17]([CH3:19])=O>>[CH3:19][C:17]1[O:4][C:3]([C:5]2[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][CH:6]=2)=[CH:2][C:16]=1[C:15]([O:21][CH3:22])=[O:20]

Komponenten

3

Edukt 2

HCID 7757Methyl acetoacetateHCID 127899772-Chloro-1-[4-(trifluoromethyl)phenyl]ethan-1-one

Produkt 1

HCID 21986466Methyl 2-methyl-5-[4-(trifluoromethyl)phenyl]-3-furoateAusbeute 39,4 %

Versuchsvorschrift

An operation similar to that in Example 1 (1) was performed using 2-chloro-4′-(trifluoromethyl)acetophenone (13.4 g) and methyl acetoacetate (5.8 g) to give the title compound (5.6 g, 39%) as a yellow crystal.

Quellen und Nachweise

ORD-Eintrag
ord-decea5200ac64fc8986d9dfdc9ac6483
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08309580B2

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