Ethyl 3-(methylamino)propanoate → HCID 59529433, compound

HRID 1876954Notes

Reaction equation

HRID 1876954 reaction equation
[CH3:1][C:2]1[O:3][C:4]([C:22]2[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=2)=[CH:5][C:6]=1[CH:7]([O:12][C:13]1[CH:21]=[CH:20][C:16]([C:17](O)=[O:18])=[CH:15][CH:14]=1)[CH2:8][CH:9]([CH3:11])[CH3:10].[CH3:32][NH:33][CH2:34][CH2:35][C:36]([O:38]CC)=[O:37]>>[CH3:1][C:2]1[O:3][C:4]([C:22]2[CH:23]=[CH:24][C:25]([C:28]([F:30])([F:29])[F:31])=[CH:26][CH:27]=2)=[CH:5][C:6]=1[CH:7]([O:12][C:13]1[CH:21]=[CH:20][C:16]([C:17]([N:33]([CH3:32])[CH2:34][CH2:35][C:36]([OH:38])=[O:37])=[O:18])=[CH:15][CH:14]=1)[CH2:8][CH:9]([CH3:11])[CH3:10]

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68512056HCID 68512056, compound

Product 1

HCID 59529433HCID 59529433, compoundYield 87%

Procedure

An operation similar to that in Example 1 (4) was performed using 4-(1-{2-methyl-5-[4-(trifluoromethyl)phenyl]-3-furyl}-3-methylbutoxy)benzoic acid (99 mg) as well as ethyl 3-(methylamino)propanoate (37 mg) to give the title compound (103 mg, 87%) as an amorphous compound.

Sources & evidence

ORD record
ord-f5c8fa6262584eb5b7eec31da0a421b0
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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