Ethyl 3-(methylamino)propanoate → HCID 59529534, compound

HRID 1876958Notes

Reaction equation

HRID 1876958 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([CH3:13])=[C:10]([CH:14]([O:19][C:20]3[CH:28]=[CH:27][C:23]([C:24](O)=[O:25])=[CH:22][CH:21]=3)[CH2:15][CH:16]([CH3:18])[CH3:17])[CH:9]=2)=[CH:4][CH:3]=1.[CH3:29][NH:30][CH2:31][CH2:32][C:33]([O:35]CC)=[O:34]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][C:11]([CH3:13])=[C:10]([CH:14]([O:19][C:20]3[CH:28]=[CH:27][C:23]([C:24]([N:30]([CH3:29])[CH2:31][CH2:32][C:33]([OH:35])=[O:34])=[O:25])=[CH:22][CH:21]=3)[CH2:15][CH:16]([CH3:18])[CH3:17])[CH:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68514138HCID 68514138, compound

Product 1

HCID 59529534HCID 59529534, compoundYield 86%

Procedure

An operation similar to that in Example 1 (4) was performed using 4-{1-[5-(4-chlorophenyl)-2-methyl-3-furyl]-3-methylbutoxy}benzoic acid (128 mg) as well as ethyl 3-(methylamino)propanoate (47 mg) to give the title compound (124 mg, 86%) as an amorphous compound.

Sources & evidence

ORD record
ord-a0fc153117da46829ac11010e1816333
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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