Ethyl 3-(methylamino)propanoate → HCID 59529505, compound

HRID 1876960Notes

Reaction equation

HRID 1876960 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([CH3:13])=[C:10]([CH:14]([CH:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)[O:15][C:16]3[CH:24]=[CH:23][C:19]([C:20](O)=[O:21])=[CH:18][CH:17]=3)[CH:9]=2)=[CH:4][CH:3]=1.[CH3:31][NH:32][CH2:33][CH2:34][C:35]([O:37]CC)=[O:36]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([CH3:13])=[C:10]([CH:14]([CH:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)[O:15][C:16]3[CH:17]=[CH:18][C:19]([C:20]([N:32]([CH3:31])[CH2:33][CH2:34][C:35]([OH:37])=[O:36])=[O:21])=[CH:23][CH:24]=3)[CH:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68514293HCID 68514293, compound

Product 1

HCID 59529505HCID 59529505, compoundYield 99.3%

Procedure

An operation similar to that in Example 1 (4) was performed using 4-{[5-(4-chlorophenyl)-2-methyl-3-furyl](cyclohexyl)methoxy}benzoic acid (120 mg) as well as ethyl 3-(methylamino)propanoate (47 mg) to give the title compound (143 mg, 93%) as an amorphous compound.

Sources & evidence

ORD record
ord-56e592bd90994e8889411b4eabf9173a
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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