Ethyl 3-(methylamino)propanoate → HCID 59529493, compound

HRID 1876962Notes

Reaction equation

HRID 1876962 reaction equation
[CH2:1]([C:3]1[O:4][C:5]([C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=2)=[CH:6][C:7]=1[CH:8]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[O:9][C:10]1[CH:18]=[CH:17][C:13]([C:14](O)=[O:15])=[CH:12][CH:11]=1)[CH3:2].[CH3:35][NH:36][CH2:37][CH2:38][C:39]([O:41]CC)=[O:40]>>[CH2:1]([C:3]1[O:4][C:5]([C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:32])([F:34])[F:33])=[CH:27][CH:26]=2)=[CH:6][C:7]=1[CH:8]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[O:9][C:10]1[CH:18]=[CH:17][C:13]([C:14]([N:36]([CH3:35])[CH2:37][CH2:38][C:39]([OH:41])=[O:40])=[O:15])=[CH:12][CH:11]=1)[CH3:2]

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68511033HCID 68511033, compound

Product 1

HCID 59529493HCID 59529493, compoundYield 98%

Procedure

An operation similar to that in Example 1 (4) was performed using 4-[{2-ethyl-5-[4-(trifluoromethyl)phenyl]-3-furyl}(phenyl)methoxy]benzoic acid (117 mg) as well as ethyl 3-(methylamino)propanoate (39 mg) to give the title compound (117 mg, 98%) as an amorphous compound.

Sources & evidence

ORD record
ord-2f525074b6704ffa93fa54a77fbf60d2
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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