Methyl acetoacetate → HCID 68515577, compound

HRID 1876966Notes

Reaction equation

HRID 1876966 reaction equation
ClC1C=CC=CC=1[CH2:8][C:9]([C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:12]=1[F:18])=O.[C:19]([O:25][CH3:26])(=[O:24])[CH2:20][C:21]([CH3:23])=[O:22]>>[F:18][C:12]1[CH:13]=[C:14]([F:17])[CH:15]=[CH:16][C:11]=1[C:9]1[O:22][C:21]([CH3:23])=[C:20]([C:19]([O:25][CH3:26])=[O:24])[CH:8]=1

Participants

3

Reactant 2

HCID 7757Methyl acetoacetateHCID 43337700HCID 43337700, compound

Product 1

HCID 68515577HCID 68515577, compoundYield 57.3%

Procedure

An operation similar to that in Example 1 (1) was performed using 2-chloro-2′,4′-difluorophenylacetophenone (19 g) and methyl acetoacetate (11 g) to give the title compound (10.3 g, 41%) as a yellow crystal.

Sources & evidence

ORD record
ord-aadaf4aea2ec4b908fb9e155f926e28c
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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