Ethyl 3-(methylamino)propanoate → HCID 59529517, compound

HRID 1876968Notes

Reaction equation

HRID 1876968 reaction equation
[CH:1]1([CH:7]([C:18]2[CH:22]=[C:21]([C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:24]=3[F:30])[O:20][C:19]=2[CH3:31])[O:8][C:9]2[CH:17]=[CH:16][C:12]([C:13](O)=[O:14])=[CH:11][CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:32][NH:33][CH2:34][CH2:35][C:36]([O:38]CC)=[O:37]>>[CH:1]1([CH:7]([C:18]2[CH:22]=[C:21]([C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:24]=3[F:30])[O:20][C:19]=2[CH3:31])[O:8][C:9]2[CH:17]=[CH:16][C:12]([C:13]([N:33]([CH3:32])[CH2:34][CH2:35][C:36]([OH:38])=[O:37])=[O:14])=[CH:11][CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68509153HCID 68509153, compound

Product 1

HCID 59529517HCID 59529517, compoundYield 95%

Procedure

An operation similar to that in Example 1 (4) was performed using 4-{cyclohexyl[5-(2,4-difluorophenyl)-2-methyl-3-furyl]methoxy}benzoic acid (235 mg) as well as ethyl 3-(methylamino)propanoate (86 mg) to give the title compound (267 mg, 95%) as an amorphous compound.

Sources & evidence

ORD record
ord-faf3f22f7b2f474ab25ccaa238a570ef
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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