Ethyl 3-(methylamino)propanoate → HCID 59529377, compound

HRID 1876969Notes

Reaction equation

HRID 1876969 reaction equation
[CH:1]1([CH:7]([NH:22][C:23]2[CH:31]=[CH:30][C:26]([C:27]([OH:29])=O)=[CH:25][CH:24]=2)[C:8]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=3[F:20])[O:10][C:9]=2[CH3:21])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:32][NH:33][CH2:34][CH2:35][C:36]([O:38]CC)=[O:37]>>[CH:1]1([CH:7]([NH:22][C:23]2[CH:24]=[CH:25][C:26]([C:27]([N:33]([CH3:32])[CH2:34][CH2:35][C:36]([OH:38])=[O:37])=[O:29])=[CH:30][CH:31]=2)[C:8]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=3[F:20])[O:10][C:9]=2[CH3:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68516510HCID 68516510, compound

Product 1

HCID 59529377HCID 59529377, compoundYield 76%

Procedure

An operation similar to that in Example 1 (4) was performed using 4-({cyclohexyl[5-(2,4-difluorophenyl)-2-methyl-3-furyl]methyl}amino)benzoic acid (511 mg) as well as ethyl 3-(methylamino)propanoate (197 mg) to give the title compound (464 mg, 76%) as an amorphous compound.

Sources & evidence

ORD record
ord-230a2f203bdb456d8edb9ab85e7e7fbc
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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