Ethyl 3-(methylamino)propanoate → HCID 59529529, compound

HRID 1876971Notes

Reaction equation

HRID 1876971 reaction equation
[CH:1]1([CH:7]([C:18]2[CH:22]=[C:21]([C:23]3[CH:28]=[CH:27][C:26]([O:29][C:30]([F:33])([F:32])[F:31])=[CH:25][CH:24]=3)[O:20][C:19]=2[CH3:34])[O:8][C:9]2[CH:17]=[CH:16][C:12]([C:13]([OH:15])=O)=[CH:11][CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:35][NH:36][CH2:37][CH2:38][C:39]([O:41]CC)=[O:40]>>[CH:1]1([CH:7]([C:18]2[CH:22]=[C:21]([C:23]3[CH:24]=[CH:25][C:26]([O:29][C:30]([F:31])([F:33])[F:32])=[CH:27][CH:28]=3)[O:20][C:19]=2[CH3:34])[O:8][C:9]2[CH:10]=[CH:11][C:12]([C:13]([N:36]([CH3:35])[CH2:37][CH2:38][C:39]([OH:41])=[O:40])=[O:15])=[CH:16][CH:17]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68512511HCID 68512511, compound

Product 1

HCID 59529529HCID 59529529, compoundYield 96%

Procedure

An operation similar to that in Example 1 (4) was performed using 4-(cyclohexyl{2-methyl-5-[4-(trifluoromethoxy)phenyl]-3-furyl}methoxy)benzoic acid (119 mg) as well as ethyl 3-(methylamino)propanoate (39 mg) to give the title compound (134 mg, 96%) as an amorphous compound.

Sources & evidence

ORD record
ord-7c5b86e961cf4cfdb8b7a1e8696c904d
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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