Ethyl 3-(methylamino)propanoate → HCID 59529424, compound

HRID 1876975Notes

Reaction equation

HRID 1876975 reaction equation
[CH:1]1([CH:7]([NH:25][C:26]2[CH:34]=[CH:33][C:29]([C:30](O)=[O:31])=[CH:28][CH:27]=2)[C:8]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([O:19][C:20]([F:23])([F:22])[F:21])=[CH:15][CH:14]=3)[O:10][C:9]=2[CH3:24])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:35][NH:36][CH2:37][CH2:38][C:39]([O:41]CC)=[O:40]>>[CH:1]1([CH:7]([NH:25][C:26]2[CH:27]=[CH:28][C:29]([C:30]([N:36]([CH3:35])[CH2:37][CH2:38][C:39]([OH:41])=[O:40])=[O:31])=[CH:33][CH:34]=2)[C:8]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([O:19][C:20]([F:22])([F:23])[F:21])=[CH:15][CH:14]=3)[O:10][C:9]=2[CH3:24])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68512459HCID 68512459, compound

Product 1

HCID 59529424HCID 59529424, compoundYield 96%

Procedure

An operation similar to that in Example 1 (4) was performed using 4-[(cyclohexyl{2-methyl-5-[4-(trifluoromethoxy)phenyl]-3-furyl}methyl)amino]benzoic acid (355 mg) as well as ethyl 3-(methylamino)propanoate (118 mg) to give the title compound (401 mg, 96%) as an amorphous compound.

Sources & evidence

ORD record
ord-e19875a8326946f3b1c11a776c221cc4
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

Loading…