Ethyl 3-(methylamino)propanoate → HCID 59529316, compound

HRID 1876979Notes

Reaction equation

HRID 1876979 reaction equation
[CH:1]1([CH:7]([C:18]2[CH:22]=[C:21]([C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:24]=3[CH3:30])[O:20][C:19]=2[CH3:31])[O:8][C:9]2[CH:17]=[CH:16][C:12]([C:13](O)=[O:14])=[CH:11][CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:32][NH:33][CH2:34][CH2:35][C:36]([O:38]CC)=[O:37]>>[CH:1]1([CH:7]([C:18]2[CH:22]=[C:21]([C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:24]=3[CH3:30])[O:20][C:19]=2[CH3:31])[O:8][C:9]2[CH:10]=[CH:11][C:12]([C:13]([N:33]([CH3:32])[CH2:34][CH2:35][C:36]([OH:38])=[O:37])=[O:14])=[CH:16][CH:17]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68509049HCID 68509049, compound

Product 1

HCID 59529316HCID 59529316, compoundYield 76%

Procedure

An operation similar to that in Example 1 (4) was performed using 4-{cyclohexyl[5-(4-fluoro-2-methylphenyl)-2-methyl-3-furyl]methoxy}benzoic acid (139 mg) as well as ethyl 3-(methylamino)propanoate (52 mg) to give the title compound (127 mg, 76%) as an amorphous compound.

Sources & evidence

ORD record
ord-d5bd3f58f4d842fda9190bda9e369bba
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

Loading…