Ethyl 3-(methylamino)propanoate → HCID 59529393, compound

HRID 1876982Notes

Reaction equation

HRID 1876982 reaction equation
[C:1]([C:5]1[O:9][C:8]([CH3:10])=[C:7]([CH:11]([CH:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)[O:12][C:13]2[CH:21]=[CH:20][C:16]([C:17](O)=[O:18])=[CH:15][CH:14]=2)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:28][NH:29][CH2:30][CH2:31][C:32]([O:34]CC)=[O:33]>>[C:1]([C:5]1[O:9][C:8]([CH3:10])=[C:7]([CH:11]([CH:22]2[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]2)[O:12][C:13]2[CH:14]=[CH:15][C:16]([C:17]([N:29]([CH3:28])[CH2:30][CH2:31][C:32]([OH:34])=[O:33])=[O:18])=[CH:20][CH:21]=2)[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68515443HCID 68515443, compound

Product 1

HCID 59529393HCID 59529393, compoundYield 81%

Procedure

An operation similar to that in Example 1 (4) was performed using 4-[(5-tert-butyl-2-methyl-3-furyl)(cyclohexyl)methoxy]benzoic acid (111 mg) as well as ethyl 3-(methylamino)propanoate (47 mg) to give the title compound (110 mg, 81%) as an amorphous compound.

Sources & evidence

ORD record
ord-6ee4558643e24d7fad352fc69a6bcaf1
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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