Ethyl 3-(methylamino)propanoate → HCID 59529587, compound

HRID 1876984Notes

Reaction equation

HRID 1876984 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([CH3:13])=[C:10]([CH:14]([CH:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)[O:15][C:16]3[CH:24]=[CH:23][C:19]([C:20](O)=[O:21])=[CH:18][CH:17]=3)[CH:9]=2)=[C:4]([CH3:31])[CH:3]=1.[CH3:32][NH:33][CH2:34][CH2:35][C:36]([O:38]CC)=[O:37]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([CH3:13])=[C:10]([CH:14]([CH:25]3[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]3)[O:15][C:16]3[CH:24]=[CH:23][C:19]([C:20]([N:33]([CH3:32])[CH2:34][CH2:35][C:36]([OH:38])=[O:37])=[O:21])=[CH:18][CH:17]=3)[CH:9]=2)=[C:4]([CH3:31])[CH:3]=1

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68514197HCID 68514197, compound

Product 1

HCID 59529587HCID 59529587, compoundYield 100.3%

Procedure

An operation similar to that in Example 1 (4) was performed using 4-{[5-(4-chloro-2-methylphenyl)-2-methyl-3-furyl](cyclohexyl)methoxy}benzoic acid (162 mg) as well as ethyl 3-(methylamino)propanoate (59 mg) to give the title compound (194 mg, 99%) as an amorphous compound.

Sources & evidence

ORD record
ord-d01761a0391a4b92941642a859dadbed
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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