HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(methylamino)propanoate → 3-[({4-[(Cyclohexyl{2-ethyl-5-[4-(trifluoromethyl)phenyl]thiophen-3-yl}methyl)amino]phenyl}carbonyl)(methyl)amino]propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(methylamino)propanoate | HCID 541480 | — |
| Reactant | 4-[(Cyclohexyl{2-ethyl-5-[4-(trifluoromethyl)phenyl]thiophen-3-yl}methyl)amino]benzoic acid | HCID 68508107 | — |
| Product | 3-[({4-[(Cyclohexyl{2-ethyl-5-[4-(trifluoromethyl)phenyl]thiophen-3-yl}methyl)amino]phenyl}carbonyl)(methyl)amino]propanoic acid | HCID 59529357 | 46.1% |
Reaction Steps
An operation similar to that in Example 69 (9) was performed using 4-[(cyclohexyl{2-ethyl-5-[4-(trifluoromethyl)phenyl]thiophen-3-yl}methyl)amino]benzoic acid (143 mg) synthesized in Example 71 (2) and ethyl 3-(methylamino)propanoate (45.9 mg) to give the title compound (77.4 mg, 46%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309580B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-bdedee42a001442aac4a434086f784a2 |
| Source note | uspto-grants-2012_11 |