Ethyl 3-(methylamino)propanoate → HCID 59529461, compound

HRID 1877000Notes

Reaction equation

HRID 1877000 reaction equation
[CH:1]1([CH:7]([C:18]2[CH:22]=[C:21]([CH:23]([CH2:26][CH3:27])[CH2:24][CH3:25])[S:20][C:19]=2[CH2:28][CH3:29])[O:8][C:9]2[CH:17]=[CH:16][C:12]([C:13](O)=[O:14])=[CH:11][CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:30][NH:31][CH2:32][CH2:33][C:34]([O:36]CC)=[O:35]>>[CH:1]1([CH:7]([C:18]2[CH:22]=[C:21]([CH:23]([CH2:26][CH3:27])[CH2:24][CH3:25])[S:20][C:19]=2[CH2:28][CH3:29])[O:8][C:9]2[CH:17]=[CH:16][C:12]([C:13]([N:31]([CH3:30])[CH2:32][CH2:33][C:34]([OH:36])=[O:35])=[O:14])=[CH:11][CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68513317HCID 68513317, compound

Product 1

HCID 59529461HCID 59529461, compoundYield 39%

Procedure

An operation similar to that in Example 69 (9) was performed using 4-{cyclohexyl[2-ethyl-5-(1-ethylpropyl)thiophen-3-yl]methoxy}benzoic acid (212 mg) synthesized in Example 73 (5) and ethyl 3-(methylamino)propanoate (80.4 mg) to give the title compound (99.2 mg, 39%).

Sources & evidence

ORD record
ord-7895ea52e97f4afab86cd333f3b1397f
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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