Ethyl 3-(methylamino)propanoate → HCID 59529347, compound

HRID 1877001Notes

Reaction equation

HRID 1877001 reaction equation
[CH:1]1([CH:7]([NH:20][C:21]2[CH:29]=[CH:28][C:24]([C:25](O)=[O:26])=[CH:23][CH:22]=2)[C:8]2[CH:12]=[C:11]([CH:13]([CH2:16][CH3:17])[CH2:14][CH3:15])[S:10][C:9]=2[CH2:18][CH3:19])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:30][NH:31][CH2:32][CH2:33][C:34]([O:36]CC)=[O:35]>>[CH:1]1([CH:7]([NH:20][C:21]2[CH:22]=[CH:23][C:24]([C:25]([N:31]([CH3:30])[CH2:32][CH2:33][C:34]([OH:36])=[O:35])=[O:26])=[CH:28][CH:29]=2)[C:8]2[CH:12]=[C:11]([CH:13]([CH2:16][CH3:17])[CH2:14][CH3:15])[S:10][C:9]=2[CH2:18][CH3:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68507744HCID 68507744, compound

Product 1

HCID 59529347HCID 59529347, compoundYield 62%

Procedure

An operation similar to that in Example 69 (9) was performed using 4-({cyclohexyl[2-ethyl-5-(1-ethylpropyl)thiophen-3-yl]methyl}amino)benzoic acid (250 mg) synthesized in Example 75 (2) and ethyl 3-(methylamino)propanoate (95.1 mg) to give the title compound (186 mg, 62%).

Sources & evidence

ORD record
ord-4b8cd5c6ccb242e7bb4c4cdd8d9ad6e6
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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