HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(methylamino)propanoate → 3-[({4-[Cyclohexyl(5-cyclohexyl-2-ethylthiophen-3-yl)methoxy]phenyl}carbonyl)(methyl)amino]propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(methylamino)propanoate | HCID 541480 | — |
| Reactant | 4-[Cyclohexyl(5-cyclohexyl-2-ethylthiophen-3-yl)methoxy]benzoic acid | HCID 68512400 | — |
| Product | 3-[({4-[Cyclohexyl(5-cyclohexyl-2-ethylthiophen-3-yl)methoxy]phenyl}carbonyl)(methyl)amino]propanoic acid | HCID 59529413 | 43% |
Reaction Steps
An operation similar to that in Example 69 (9) was performed using 4-[cyclohexyl(5-cyclohexyl-2-ethylthiophen-3-yl)methoxy]benzoic acid (200 mg) synthesized in Example 77 (4) and ethyl 3-(methylamino)propanoate (73.8 mg) to give the title compound (103 mg, 43%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309580B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-76448f8317304672b395670e44a57462 |
| Source note | uspto-grants-2012_11 |