Ethyl 3-(methylamino)propanoate → HCID 68512543, compound

HRID 1877007Notes

Reaction equation

HRID 1877007 reaction equation
[CH:1]1([CH:7]([NH:21][C:22]2[CH:30]=[CH:29][C:25]([C:26](O)=[O:27])=[CH:24][CH:23]=2)[C:8]2[CH:12]=[C:11]([CH:13]3[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]3)[S:10][C:9]=2[CH2:19][CH3:20])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:31][NH:32][CH2:33][CH2:34][C:35]([O:37]CC)=[O:36]>>[CH:1]1([CH:7]([NH:21][C:22]2[CH:23]=[CH:24][C:25]([C:26]([N:32]([CH3:31])[CH2:33][CH2:34][C:35]([OH:37])=[O:36])=[O:27])=[CH:29][CH:30]=2)[C:8]2[CH:12]=[C:11]([CH:13]3[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]3)[S:10][C:9]=2[CH2:19][CH3:20])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68511659HCID 68511659, compound

Product 1

HCID 68512543HCID 68512543, compoundYield 74.4%

Procedure

An operation similar to that in Example 69 (9) was performed using 4-{[cyclohexyl(5-cyclohexyl-2-ethylthiophen-3-yl)methyl]amino}benzoic acid (233 mg) synthesized in Example 79 (3) and ethyl 3-(methylamino)propanoate (86.0 mg) to give the title compound (208 mg, 74%).

Sources & evidence

ORD record
ord-022f89b73b664eea9a069ac383c4dc2f
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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