Ethyl 3-(methylamino)propanoate → HCID 59529420, compound

HRID 1877009Notes

Reaction equation

HRID 1877009 reaction equation
[CH:1]1([CH:7]([C:18]2[CH:22]=[C:21]([CH2:23][CH:24]([CH3:26])[CH3:25])[S:20][C:19]=2[CH2:27][CH3:28])[O:8][C:9]2[CH:17]=[CH:16][C:12]([C:13](O)=[O:14])=[CH:11][CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:29][NH:30][CH2:31][CH2:32][C:33]([O:35]CC)=[O:34]>>[CH:1]1([CH:7]([C:18]2[CH:22]=[C:21]([CH2:23][CH:24]([CH3:25])[CH3:26])[S:20][C:19]=2[CH2:27][CH3:28])[O:8][C:9]2[CH:17]=[CH:16][C:12]([C:13]([N:30]([CH3:29])[CH2:31][CH2:32][C:33]([OH:35])=[O:34])=[O:14])=[CH:11][CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68515062HCID 68515062, compound

Product 1

HCID 59529420HCID 59529420, compoundYield 51.2%

Procedure

An operation similar to that in Example 69 (9) was performed using 4-{cyclohexyl[2-ethyl-5-(2-methylpropyl)thiophen-3-yl]methoxy}benzoic acid (256 mg) synthesized in Example 81 (4) and ethyl 3-(methylamino)propanoate (101 mg) to give the title compound (159 mg, 51%).

Sources & evidence

ORD record
ord-bb432c133c3a49248fa2505dd5fc9326
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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