Ethyl 3-(methylamino)propanoate → HCID 59529415, compound

HRID 1877010Notes

Reaction equation

HRID 1877010 reaction equation
[CH:1]1([CH:7]([NH:19][C:20]2[CH:28]=[CH:27][C:23]([C:24](O)=[O:25])=[CH:22][CH:21]=2)[C:8]2[CH:12]=[C:11]([CH2:13][CH:14]([CH3:16])[CH3:15])[S:10][C:9]=2[CH2:17][CH3:18])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:29][NH:30][CH2:31][CH2:32][C:33]([O:35]CC)=[O:34]>>[CH:1]1([CH:7]([NH:19][C:20]2[CH:21]=[CH:22][C:23]([C:24]([N:30]([CH3:29])[CH2:31][CH2:32][C:33]([OH:35])=[O:34])=[O:25])=[CH:27][CH:28]=2)[C:8]2[CH:12]=[C:11]([CH2:13][CH:14]([CH3:15])[CH3:16])[S:10][C:9]=2[CH2:17][CH3:18])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 68511998HCID 68511998, compound

Product 1

HCID 59529415HCID 59529415, compoundYield 76.5%

Procedure

An operation similar to that in Example 69 (9) was performed using 4-({cyclohexyl[2-ethyl-5-(2-methylpropyl)thiophen-3-yl]methyl}amino)benzoic acid (250 mg) synthesized in Example 83 (1) and ethyl 3-(methylamino)propanoate (98.5 mg) to give the title compound (232 mg, 76%).

Sources & evidence

ORD record
ord-0180cdabc685424882a236f91d27369d
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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