Thionyl Chloride → 2-{4-[Chloro(cyclohexyl)methyl]-5-methylfuran-2-yl}-5-fluoropyridine

Participants

Reaction Steps

To a solution of cyclohexyl[5-(5-fluoropyridin-2-yl)-2-methylfuran-3-yl]methanol (0.7 g) in toluene (10 mL) was added thionyl chloride (0.3 mL), and the mixture was stirred at room temperature for 2 hr. The solvent was evaporated under reduced pressure to give the title compound (0.7 g, 100%) as a yellow crystal.

Provenance & Evidence