6-Methyl-1,2,3,4-tetrahydroquinoline → (6-Methyl-3,4-dihydro-2H-quinolin-1-yl)-[2-(3-trifluoromethyl-phenoxy)-pyridin-3-yl]-methanone

HRID 1877346Notes

Reaction equation

HRID 1877346 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:4]=[C:5]([CH:16]=[CH:17][CH:18]=1)[O:6][C:7]1[N:15]=[CH:14][CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=O.[CH3:21][C:22]1[CH:23]=[C:24]2[C:29](=[CH:30][CH:31]=1)[NH:28][CH2:27][CH2:26][CH2:25]2>>[CH3:21][C:22]1[CH:23]=[C:24]2[C:29](=[CH:30][CH:31]=1)[N:28]([C:9]([C:8]1[C:7]([O:6][C:5]3[CH:16]=[CH:17][CH:18]=[C:3]([C:2]([F:1])([F:20])[F:19])[CH:4]=3)=[N:15][CH:14]=[CH:13][CH:12]=1)=[O:11])[CH2:27][CH2:26][CH2:25]2

Participants

3

Reactant 2

HCID 666786-Methyl-1,2,3,4-tetrahydroquinolineHCID 2158912-(3-(Trifluoromethyl)phenoxy)-3-pyridinecarboxylic acid

Product 1

HCID 46194169(6-Methyl-3,4-dihydro-2H-quinolin-1-yl)-[2-(3-trifluoromethyl-phenoxy)-pyridin-3-yl]-methanone

Procedure

The title compound was prepared from 2-(3-trifluoromethyl-phenoxy)-nicotinic acid in analogy to Example 1, Step 2, by replacing 1,2,3,4-tetrahydro-quinoline with 6-methyl-1,2,3,4-tetrahydro-quinoline ([CAS RN 91-61-2]). MS (ISP): 413.2 [M+H]+.

Sources & evidence

ORD record
ord-349be3fe31f9442c84cb3cf15b555dbf
Source dataset
uspto-grants-2012_11
Patent number
US08309734B2

Reaction notes

Loading…