HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-1,2,3,4-tetrahydroquinoline → [2-(3-Chloro-4-fluoro-phenoxy)-pyridin-3-yl]-(3,4-dihydro-2H-[1,5]naphthyridin-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-1,2,3,4-tetrahydroquinoline | HCID 96289 | — |
| Reactant | 1,2,3,4-Tetrahydro-1,5-naphthyridine | HCID 6917495 | — |
| Reactant | 2-(3-Chloro-4-fluoro-phenoxy)-nicotinic acid | HCID 12849337 | — |
| Reactant | 2-(2,5-Dichloro-phenoxy)-nicotinic acid | HCID 16795996 | — |
| Product | [2-(3-Chloro-4-fluoro-phenoxy)-pyridin-3-yl]-(3,4-dihydro-2H-[1,5]naphthyridin-1-yl)-methanone | HCID 59294527 | — |
Reaction Steps
The title compound was prepared in analogy to Example 67 replacing 2-(2,5-dichloro-phenoxy)-nicotinic acid with 2-(3-chloro-4-fluoro-phenoxy)-nicotinic acid (Example 77, Step 1) and 2-methyl-1,2,3,4-tetrahydro-quinoline with 1,2,3,4-tetrahydro-[1,5]naphthyridine ([CAS RN 13993-61-8]). MS (ISN): 383.9 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309734B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-68ed5bd1d7ac4141bf7a1c0a06eb161d |
| Source note | uspto-grants-2012_11 |