2,5-Dichlorophenol → 2-(2,5-Dichloro-phenoxy)-5-fluoro-nicotinic acid

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Reaction Steps

2-(2,5-Dichloro-phenoxy)-5-fluoro-nicotinic acid was prepared in analogy to Example 1, Step 1, replacing 2-chloro-nicotinic acid with 2-chloro-5-fluoro-nicotinic acid ([CAS RN 38186-88-8]) and 3-trifluoromethyl-phenol with 2,5-dichloro-phenol ([CAS RN 583-78-8]). 1H NMR (400 MHz, DMSO): δ7.38 (dd, J=8.4 Hz, J=2.4 Hz, 1H), 7.51 (d, J=2.4 Hz, 1H), 7.62 (d, J=8.4 Hz, 1H), 8.23 (dd, J=8.1 Hz, J=3.2 Hz, 1H), 8.34 (d, J=3.2 Hz, 1H), 13.65 (s, 1H). 19F NMR (376.5 MHz, DMSO): −134.6. MS (ISN): 302.0 [M−H]−.

Provenance & Evidence