3-(Trifluoromethyl)phenol → HCID 67367227, compound

Participants

Reaction Steps

2-(3-Chloro-4-fluoro-phenoxy)-5-fluoro-nicotinic acid was prepared in analogy to Example 1, Step 1, replacing 2-chloro-nicotinic acid with 2-chloro-5-fluoro-nicotinic acid ([CAS RN 38186-88-8]) and 3-trifluoromethyl-phenol with 3-chloro-4-fluoro-phenol ([CAS RN 2613-23-2]). 1H NMR (400 MHz, DMSO): δ7.16-7.19 (m, 1H), 7.44-7.48 (m, 2H), 8.19 (dd, J=8.1 Hz, J=3.2 Hz, 1H), 8.35 (d, J=3.2 Hz, 1H), 13.60 (s, 1H). 19F NMR (376.5 MHz, DMSO): −121.6, −134.8. MS (ISN): 283.8 [M−H]−.

Provenance & Evidence