6-Methyl-1,2,3,4-tetrahydroquinoline → HCID 46195422, compound

HRID 1877374Notes

Reaction equation

HRID 1877374 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[F:19])[O:5][C:6]1[N:14]=[CH:13][C:12]([F:15])=[CH:11][C:7]=1[C:8]([OH:10])=O.C[C:21]1[CH:22]=[C:23]2[C:28](=[CH:29][CH:30]=1)[NH:27][CH2:26][CH2:25][CH2:24]2.N1C2C(=CC=CC=2)CCC1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[F:19])[O:5][C:6]1[C:7]([C:8]([N:27]2[C:28]3[C:23](=[CH:22][CH:21]=[CH:30][CH:29]=3)[CH2:24][CH2:25][CH2:26]2)=[O:10])=[CH:11][C:12]([F:15])=[CH:13][N:14]=1

Participants

4

Reactant 3

HCID 666786-Methyl-1,2,3,4-tetrahydroquinolineHCID 694601,2,3,4-TetrahydroquinolineHCID 67367227HCID 67367227, compound

Product 1

HCID 46195422HCID 46195422, compound

Procedure

The title compound was prepared in analogy to Example 31, Step 2, replacing 2-(2,5-dichloro-phenoxy)-nicotinic acid with 2-(3-chloro-4-fluoro-phenoxy)-5-fluoro-nicotinic acid and 6-methyl-1,2,3,4-tetrahydro-quinoline with 1,2,3,4-tetrahydro-quinoline ([CAS RN 635-46-1]). MS (ISP): 401.0 [M+H]+.

Sources & evidence

ORD record
ord-2483beb9aaa74092bb85f2d34c2cbf00
Source dataset
uspto-grants-2012_11
Patent number
US08309734B2

Reaction notes

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