2,5-Dichlorophenol → HCID 59294546, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (3-bromo-pyridin-4-yl)-(3,4-dihydro-2H-quinolin-1-yl)-methanone (41.2 mg, 0.13 mmol, 1.0 equiv) and 2,5-dichloro-phenol (21.2 mg, 0.13 mmol, 1.0 equiv; [CAS RN 583-78-8]) in DMAc (1 mL) was added potassium carbonate (35.9 mg, 0.26 mmol, 2.0 equiv; [CAS RN 584-08-7]) and copper(I) iodide (5.0 mg, 0.026 mmol, 0.2 equiv; [CAS RN 7681-65-4]). The reaction mixture was heated by microwave irradiation to 180° C. for 8 h. Purification by preparative HPLC on reversed phase (Xterra® PrepMSC 18, 5 μm, 19×50 mm column equipped with a Gilson Liquid Handler 215 autosampler, two Rainin Dynamax® SD-300 pumps, a Sedex ELSD 75 lightscatter and a Dionex UVD 340S UV detector) eluting with a gradient of acetonitrile/water provided 5 mg (10%) of the title compound. MS (ISP): 399.1 [M+H]+.

Provenance & Evidence