2-Chloro-4-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-2-yloxy]-phenylethynyl}-benzoic acid methyl ester → 4-(2-{2,5-Dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-2-yloxy]-phenyl}-ethyl)-benzoic acid
Reaction equation
C[O:2][C:3](=[O:43])[C:4]1[CH:9]=[CH:8][C:7]([C:10]#[C:11][C:12]2[CH:17]=[C:16]([Cl:18])[C:15]([O:19][C:20]3[C:25]([C:26]([N:28]4[C:37]5[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=5)[N:31]([CH:38]5[CH2:40][CH2:39]5)[CH2:30][CH2:29]4)=[O:27])=[CH:24][CH:23]=[CH:22][N:21]=3)=[CH:14][C:13]=2[Cl:41])=[CH:6][C:5]=1Cl.COC(=O)C1C=CC(C#CC2C=C(Cl)C(OC3C(C(N4C5C(=CC=CC=5)N(C5CC5)CC4)=O)=CC=CN=3)=CC=2Cl)=CC=1>>[Cl:41][C:13]1[CH:14]=[C:15]([O:19][C:20]2[C:25]([C:26]([N:28]3[C:37]4[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=4)[N:31]([CH:38]4[CH2:40][CH2:39]4)[CH2:30][CH2:29]3)=[O:27])=[CH:24][CH:23]=[CH:22][N:21]=2)[C:16]([Cl:18])=[CH:17][C:12]=1[CH2:11][CH2:10][C:7]1[CH:6]=[CH:5][C:4]([C:3]([OH:43])=[O:2])=[CH:9][CH:8]=1Participants
3
Reactant 2
Product 1
Procedure
The title compound was prepared in analogy to Example 168 replacing 2-chloro-4-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-2-yloxy]-phenylethynyl}-benzoic acid methyl ester with 4-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-2-yloxy]-phenylethynyl}-benzoic acid methyl ester. MS (ISP): 588.2 [M+H]+.
Sources & evidence
- ORD record
- ord-b1737fa1258049d5996f9c68e128f336
- Source dataset
- uspto-grants-2012_11
- Patent number
- US08309734B2
Reaction notes
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