Sodium Hydroxide → HCID 67307516, compound

Participants

Reaction Conditions

Reaction Steps

1.6 ml of 2M sodium hydroxide are added to a solution of 0.33 g of 9-(5-cyanopyridin-2-yl)-9H-carbazole-4-carboxylic acid methyl ester, obtained according to the preceding stage, in 30 ml of methanol, and then the mixture is heated at 60° C. for 2 hours. After a return to ambient temperature, the reaction mixture is concentrated under reduced pressure, and then 20 ml of water and a 1M aqueous solution of HCl are added in order to bring the pH to around 6. The aqueous phase is extracted with 3×100 ml of ethyl acetate, and the organic phases are then combined, dried over magnesium sulphate and concentrated under reduced pressure. 0.24 g of 9-(5-carbamoylpyridin-2-yl)-9H-carbazole-4-carboxylic acid is thus obtained in the form of a rubbery residue, the characteristics of which are the following:

Provenance & Evidence