Hydrogen Peroxide → HCID 58338283, compound

Participants

Reaction Steps

The process is carried out as in stage 3 of Example 3, but using 500 mg of 2-fluoro-4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]benzonitrile, obtained according to stage 2 of Example 3, 493 mg of potassium carbonate, 1.78 g of 2-fluoroethylamine hydrochloride and 1.805 g of triethylamine in 5 ml of dimethyl sulphoxide. 2.26 ml of a 1M aqueous solution of sodium hydroxide, 2.19 ml of a 30% aqueous solution of hydrogen peroxide and 10 ml of ethanol are then added to the reaction medium. After treatment as in stage 3 of Example 3, and then purification by flash chromatography on silica gel, elution being carried out with a mixture of dichloromethane and ethanol (95/5 by volume), followed by crystallization from 1 ml of ethyl acetate, 390 mg of 4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]-2-(2-fluoroethylamino)benzamide are thus obtained in the form of a beige solid, the characteristics of which are the following:

Provenance & Evidence