Hydrogen Peroxide → HCID 58338214, compound

Participants

Reaction Steps

The process is carried out as in stage 3 of Example 3, but using 150 mg of 2-fluoro-4-[4-(6-fluoro-1H-benzimidazol-2-yl)-carbazol-9-yl]benzonitrile, obtained according to stage 2 of Example 3, 148 mg of potassium carbonate and 0.772 g of 2-(aminomethyl)pyridine in 2 ml of dimethyl sulphoxide. 0.678 ml of a 1M aqueous solution of sodium hydroxide, 0.656 ml of a 30% aqueous solution of hydrogen peroxide and 3 ml of ethanol are then added to the reaction medium. After treatment as in stage 3 of Example 3, and then purification by flash chromatography on silica gel, elution being carried out with mixtures of dichloromethane and a 7M solution of ammonia in methanol (from 95/5 to 80/20 by volume), followed by crystallization from 2 ml of ethyl acetate, 75 mg of 4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]-2-[(pyridin-2-ylmethyl)amino]benzamide are thus obtained in the form of a beige solid, the characteristics of which are the following:

Provenance & Evidence