Hydrogen Peroxide → HCID 58338237, compound

Participants

Reaction Steps

The process is carried out as in stage 3 of Example 3, but using 160 mg of 2-fluoro-4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]benzonitrile, obtained according to stage 2 of Example 3, 210 mg of potassium carbonate and 338.5 mg of (1-methyl-1H-imidazol-4-yl)methylamine in 3.3 ml of dimethyl sulphoxide, in a microwave for 1 hour and 30 minutes at 115° C. 0.76 ml of a 1M aqueous solution of sodium hydroxide, 0.70 ml of a 30% aqueous solution of hydrogen peroxide and 6.6 ml of ethanol are then added to the reaction medium. After treatment as in stage 3 of Example 3, and then purification by flash chromatography on silica gel, elution being carried out with a mixture of dichloromethane and ethanol (95/5 by volume), 78 mg of 4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]-2-[(1-methyl-1H-imidazol-4-yl)methylamino]benzamide are thus obtained in the form of an ecru powder, the characteristics of which are the following:

Provenance & Evidence