Hydrogen Peroxide → HCID 58338348, compound

Participants

Reaction Steps

The process is carried out as in stage 3 of Example 3, but using 168.2 mg of 2-fluoro-4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]benzonitrile, obtained according to stage 2 of Example 3, 165.8 mg of potassium carbonate, 517 mg of 2-(1-methyl-1H-imidazol-4-yl)ethylamine hydrochloride and 324 mg of triethylamine in 1.7 ml of dimethyl sulphoxide, in a microwave for 1 hour and 30 minutes at 115° C. 0.76 ml of a 1M aqueous solution of sodium hydroxide, 0.735 ml of a 30% aqueous solution of hydrogen peroxide and 4 ml of ethanol are then added to the reaction medium. After treatment as in stage 3 of Example 3, and then purification by flash chromatography on 10 g of silica gel, elution being carried out with a mixture of dichloromethane and methanol (95/5 by volume), 34 mg of 4-[4-(6-fluoro-1H-benzimidazol-2-y0-9H-carbazol-9-yl]-2-[(1-methyl-1H-imidazol-4-yl)ethylamino]benzamide are thus obtained in the form of a white solid, the characteristics of which are the following:

Provenance & Evidence