L-Alanine → Poliglecaprone

HRID 1877704Notes

Reaction equation

HRID 1877704 reaction equation
[C:1]1(=[O:8])[O:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:9]([OH:13])(=[O:12])[CH2:10][OH:11].N[C@H:15]([C:17](O)=[O:18])C>O1CCOCC1>[C:1]1(=[O:8])[O:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:10]1[O:11][C:17](=[O:18])[CH2:15][O:13][C:9]1=[O:12]

Participants

4

Reactant 2

HCID 5950L-AlanineHCID 118290388HCID 118290388, compound

Product 1

HCID 65431Poliglecaprone

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Conditions

Temperature
60 °C

Procedure

A 1% w/w solution of epsilon-caprolactone/glycolide copolymer in 1,4-dioxane was prepared as follows. 1.5 grams of 36/64 poly(epsilon-caprolactone-glycolic acid) copolymer, obtained from American Polymer Incorporated (American Polymer Inc., Birmingham, Ala.), were added to 148.8 grams of 1,4-dioxane (Fisher Scientific, Raritan, N.J.) in a 250 milliliter Erlenmeyer screwed cap flask. The mixture was stirred for 4 hours in 60° C. water bath set on a temperature controlled heating plate. The polymer solution was filtered through an extra coarse thimble filter to remove any undissolved solids.

Workup

  1. customscrewed cap flask
  2. temperaturecontrolled heating plate
  3. filtrationThe polymer solution was filtered through an extra coarse thimble
  4. filtrationfilter
  5. customto remove any undissolved solids

Sources & evidence

ORD record
ord-0f07527b26e34cd5bf2a459683f80a47
Source dataset
uspto-grants-2012_11
Patent number
US08313504B2

Reaction notes

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