Water → HCID 58239621, compound

Participants

Reaction Steps

1.1 g (29 mmol) of lithium aluminium hydride are initially introduced in 50 ml of THF, and a solution of 8.0 g (24.1 mmol) of 3-(3′-benzyloxy-biphenyl-3-yl)propionic acid in 50 ml of THF is added. The batch is stirred at room temp. for 1 h, heated under reflux for 1 h, added to water and acidified using dil. sulfuric acid. The aqueous phase is separated off and extracted with MTB ether. The combined org. phases are washed with water and sat. sodium chloride soln. and dried over sodium sulfate. The solvent is removed in vacuo, and the residue is employed in the next step without further purification.

Provenance & Evidence