Ethanol → HCID 640311, compound

Participants

Reaction Steps

Charge to a 500 mL Parr bottle, a mixture of 5% palladium on charcoal (0.2 g) in ethanol (25 mL) and add methyl 4-ethenyl-1H-pyrrole-2-carboxylate (1.4 g, 9.3 mmoles). Hydrogenate at 206.8 kPa for 3 h to give complete conversion by LC-MS. Filter through celite and evaporate to give an oil. Pass through a silica gel pad with iso-hexane/ethyl acetate (100:0 to 75:25) to give the title compound as a pale yellow oil (1.12 g). 1H-NMR (CDCl3), δ: 8.87 (1H, br. s), 6.73-6.78 (2H, m), 3.83 (3H, s), 2.50 (2H, q, J=7.8 Hz) and 1.19 (3H, t, J=7.3 Hz).

Provenance & Evidence