Methanesulfonic Acid → 3-[4-(7-chloro-2-methyl-5H-pyrrolo[2,1-c][1,4]benzodiazepin-11-yl)piperazin-1-yl]-2,2-dimethylpropanoic acid di-methanesulfonate

Participants

Reaction Steps

Add acetonitrile (5 mL) to 3-[4-(7-chloro-2-methyl-5H-pyrrolo[2,1-c][1,4]benzodiazepine-11-yl)piperazin-1-yl]-2,2-dimethylpropanoic acid (0.106 g, 0.255 mmol) to create a slurry. Add methanesulfonic acid (0.050 ml, 0.075 g, 0.76 mmol) to the stirring slurry (1000 rpm) and stir the resultant solution at 60° C. until a white solid precipitates. Cool this slurry, and isolate the solid by filtration to obtain 3-[4-(7-chloro-2-methyl-5H-pyrrolo[2,1-c][1,4]benzodiazepin-11-yl)piperazin-1-yl]-2,2-dimethylpropanoic acid di-methanesulfonate (0.15 g).

Provenance & Evidence