N-bromobutanimide → 4-(bromomethyl)-3-(trifluoromethyl)benzonitrile

HRID 1877912Notes

Reaction equation

HRID 1877912 reaction equation
[CH3:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11].C1C(=O)N([Br:21])C(=O)C1>>[Br:21][CH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:10]([F:11])([F:12])[F:13]

Participants

3

Reactant 2

HCID 67184N-bromobutanimideHCID 27755984-Methyl-3-(trifluoromethyl)benzonitrile

Product 1

HCID 588271604-(bromomethyl)-3-(trifluoromethyl)benzonitrile

Procedure

4-Methyl-3-trifluoromethylbenzonitrile is brominated with NBS according to Example 1A to give 4-bromomethyl-3-trifluoromethylbenzonitrile. 1H NMR (400 MHz, CDCl3) δ (ppm) 7.94 (s, 1H), 7.85 (d, J=8.1 Hz, 1H), 7.76 (d, J=8.1 Hz, 1H), 4.63 (s, 2H).

Sources & evidence

ORD record
ord-d893165fb6454b11800b59611e9071ea
Source dataset
uspto-grants-2012_11
Patent number
US08314097B2

Reaction notes

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