Hydrochloric Acid → HCID 58345409, compound

Participants

Reaction Steps

8.5 g (152 mmol) of potassium hydroxide are added to a solution of 6 g (15.2 mmol) of ethyl 1-(3-chlorophenyl)-5-[3-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylate from example 4A in 80 ml of methanol and the mixture is stirred for 30 minutes under reflux. The reaction mixture is diluted with water and rendered acidic using 1 molar hydrochloric acid. The mixture is extracted with ethyl acetate. The organic phase is washed with a sodium chloride solution, dried over sodium sulfate and concentrated on a rotary evaporator. The residue obtained is crystallized from diethyl ether/pentane. The crystals are collected by suction filtration, washed with a little pentane and dried. 5.2 g (14.2 mmol, 93% yield of theory) of product are obtained.

Provenance & Evidence